Two Old Drugs Make One New Diet Pill

New Combination Pill for Weight Loss Shows Promise

By PEGGY PECK
ABC News, MedPage Today

Sept. 10, 2009—
Patients taking a novel diet drug that combines the stimulant phentermine with the anticonvulsant topiramate lost an average of 37 pounds over a year with significant improvement in a number of heart risk factors, according to an announcement Vivus, the developer of the drug.

In a trial known as EQUIP, which involved more than 1,200 morbidly obese patients, patients who received the drug, which has the brand name Qnexa, lost weight at every tested dose, but significant weight loss — 14.7 percent on average — occurred at the highest dose.

Results from a second trial involving 2,487 overweight and obese patients with hypertension, hyperlipidemia, or type 2 diabetes, known as CONQUER, showed an average weight loss 30 pounds with full dose of the drug combination. More…

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